HORDB

ID: hor002886
Uniprot ID: P17219
Protein name: P2K
Gene name: NA
Organism: Bombyx mori (Silk moth)
Family: NA
Source: animal
Expression: PTTH is synthesized by two dorsolateral neurosecretory cells of the Bombyx brain.
Disease: NA
Comments: NA
Taxonomy: Bombyx (genus), Bombycinae (subfamily), Bombycidae (family), Bombycoidea (superfamily), Obtectomera, Ditrysia, Heteroneura (parvorder), Neolepidoptera (infraorder), Glossata (suborder), Lepidoptera (order), Amphiesmenoptera (superorder), Endopterygota (cohort), Neoptera (infraclass), Pterygota (subclass), Dicondylia, Insecta (class), Hexapoda (subphylum), Pancrustacea, Mandibulata, Arthropoda (phylum), Panarthropoda, Ecdysozoa, Protostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
GO MF: GO:0005179 hormone activity
GO BP: GO:0007218 neuropeptide signaling pathway
GO CC: NA

Sequence: PDVGGFMVEDQRTHKSHNYMM
Length: 21(33-53)
Propeptide: MITRPIILVILCYAILMIVQSFVPKAVALKRKPDVGGFMVEDQRTHKSHNYMMKRARNDVLGDKENVRPNPYYTEPFDPDTSPEELSALIVDYANMIRNDVILLDNSVETRTRKRGNIQVENQAIPDPPCTCKYKKEIEDLGENSVPRFIETRNCNKTQQPTCRPPYICKESLYSITILKRRETKSQESLEIPNELKYRWVAESHPVSVACLCTRDYQLRYNNN
Signal peptide: MITRPIILVILCYAILMIVQSFVPKAVAL
Modification: NA
Glycosylation: NA
Mutagenesis: NA

Function: PTTH is a brain secretory polypeptide of insects which stimulates the prothoracic glands to produce and release ecdysone, the steroid essential to insect development.; Peptides P2K and P6K are presumed to be cleaved post-translationally and may play some
Mechanism: NA
Cross BBB: NA
Target: NA
Target Unid: NA
IC50: NA
EC50: NA
ED50: NA
kd: NA
Half life: NA

Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)

hor002886_AF2.pdb

hor002886_ESM.pdb

Mass:	283670	Formula:	C105H159N31O33S3
Absent amino acids:	ACILW	Common amino acids:	M
pI:	6.5	Basic residues:	4
Polar residues:	6	Hydrophobic residues:	3
Hydrophobicity:	-98.1	Boman Index:	-5234
Half-Life:	>20 hour	Half-Life Yeast:	>20 hour
Half-Life E.Coli:	?	Aliphatic Index	27.62
Instability Index:	5904.29	Extinction Coefficient cystines:	1490
Absorbance 280nm:	74.5